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apalutamide will decrease the extent or result of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicine which have been CYP3A4 substrates may lead to decrease publicity to those remedies.calaspargase pegol, ethinylestrad